Cenforce 50 mg (Sildenafil Citrate) and Cialis (Tadalafil) are both used to treat erectile dysfunction (ED), but they have some important differences in terms of strength, duration of action, and mechanism of action. Here's a comparison to help clarify how they compare: Cenforce 50 mg (Sildenafil Citrate) vs. Cialis (Tadalafil) 1. Active Ingredient Cenforce 50 mg contains Sildenafil Citrate, the same active ingredient found in Viagra. Sildenafil works by increasing blood flow to the penis to help achieve and maintain an erection. Cialis contains Tadalafil, which is also a PDE5 inhibitor like Sildenafil, but it has a longer duration of action. 2. How They Work Sildenafil (Cenforce): It works by blocking the enzyme PDE5, which normally restricts blood flow to the penis. By inhibiting this enzyme, Sildenafil allows more blood to flow to the penis, facilitating an erection during sexual arousal. Tadalafil (Cialis): Works in a similar way, inhibiting PDE5, but Tadalafil stays active for a much longer time—up to 36 hours in some cases. This is why Tadalafil is sometimes referred to as the "weekend pill" since you can take it once and have a window of time where it’s effective, not needing to time your dose as precisely.