Cenforce 25 mg, like other sildenafil-based medications, should be taken approximately 30 minutes to 1 hour before sexual activity for optimal effectiveness. It is generally recommended to take it when you anticipate sexual activity, but not more than once a day. It's important to note that the medication can remain active in your system for about 4 to 6 hours after taking it, so if sexual activity Cenforce 25 mg within this time frame, the medication will likely be effective. However, if it’s too late (i.e., after this window of time has passed), the drug might not work as effectively. Here are some general guidelines: Before sexual activity: Take it 30-60 minutes in advance. After meals: If you take it after a heavy meal, the absorption of the drug may be slower, so consider planning ahead. Beyond 4-6 hours: It may not be effective, and waiting until the next planned dose is recommended. Always follow your healthcare provider's advice for the best results and safety.