Tadapox Tablet contains two active ingredients: Tadalafil (20 mg) for the treatment of erectile dysfunction (ED) and Dapoxetine (60 mg) for premature ejaculation (PE). While effective for many men, there are certain health conditions where Tadapox is contraindicated, meaning it should not be used because it can pose serious risks. Key Contraindications of Tadapox: Heart Conditions: Severe cardiovascular diseases such as recent heart attack (myocardial infarction) or stroke within the last 6 months make Tadapox unsafe, as it can increase the strain on the heart. Patients with angina (chest pain), especially when triggered by sexual activity, should avoid using this medication due to the increased risk of heart complications. Uncontrolled arrhythmias (irregular heartbeats), severe heart failure, or other serious heart conditions also contraindicate the use of Tadapox. Use of Nitrates: Nitrate medications (often used for treating chest pain or angina) are absolutely contraindicated with Tadapox. This is because the combination of tadalafil and nitrates can cause a severe drop in blood pressure, leading to fainting, shock, or even life-threatening complications. Examples of nitrates include nitroglycerin, isosorbide mononitrate, and isosorbide dinitrate. Severe Liver or Kidney Disease: Tadapox is contraindicated in people with severe liver impairment or kidney disease that requires dialysis. These conditions affect the body’s ability to metabolize and excrete the medication, which can lead to dangerous drug accumulation and side effects. Hypotension (Low Blood Pressure): If you have severe low blood pressure (hypotension), typically defined as less than 90/60 mmHg, Tadapox can further lower blood pressure to dangerous levels, which can cause dizziness, fainting, or shock. Retinal Disorders (Vision Issues): Individuals with retinitis pigmentosa, a rare genetic eye disorder, should avoid using Tadapox Tablet   because PDE5 inhibitors (like tadalafil) may interact with the enzyme that supports vision, potentially worsening retinal conditions or leading to sudden vision loss. Severe Dehydration: Severe dehydration can enhance the blood pressure-lowering effects of tadalafil, and it should be treated before using Tadapox. History of Priapism (Prolonged Erection): Men with a history of priapism (a painful, prolonged erection lasting more than 4 hours) or conditions that predispose them to priapism (e.g., sickle cell anemia, leukemia, or multiple myeloma) should not use Tadapox. The risk of priapism is increased with medications like tadalafil, which can be dangerous and lead to permanent damage to the penis. Mental Health Conditions and Dapoxetine: Since dapoxetine is an SSRI (selective serotonin reuptake inhibitor), Tadapox is contraindicated in patients with a history of severe depression, bipolar disorder, mania, or suicidal thoughts. Dapoxetine can exacerbate these conditions or trigger episodes. Tadapox should also be avoided if you are using other SSRIs, SNRIs, or MAO inhibitors, as combining them can lead to serotonin syndrome, a life-threatening condition. Allergies to Active Ingredients: If you have known allergies or hypersensitivity to tadalafil, dapoxetine, or any other component of the tablet, you should avoid using Tadapox. Severe Peptic Ulcers or Bleeding Disorders: Tadalafil may affect blood clotting, and it is contraindicated in people with severe peptic ulcers or bleeding disorders such as hemophilia. Special Precautions: Alcohol use should be limited when taking Tadapox, as it can increase the risk of side effects like dizziness, fainting, and a drop in blood pressure. Recreational drugs (poppers) containing nitrates are strictly contraindicated due to the risk of serious interactions with tadalafil. Consultation with a Healthcare Provider: Before using Tadapox, it is crucial to consult a healthcare provider, especially if you have any pre-existing health conditions. Your doctor will assess whether it is safe for you based on your health status, and they may recommend alternative treatments if Tadapox is contraindicated.