Avana 100 mg (generic name: avanafil) belongs to a class of medications known as PDE-5 inhibitors. These drugs work by blocking the enzyme phosphodiesterase type 5 (PDE-5), which normally breaks down a substance called cyclic guanosine monophosphate (cGMP). During sexual arousal, nitric oxide is released into the erectile tissue of the penis. Nitric oxide activates an enzyme called guanylate cyclase, which leads to increased levels of cGMP. Avana 100 mg cyclic guanosine monophosphate relaxes smooth muscles in blood vessels of the penis, allowing for increased blood flow. This increased blood flow is essential for achieving and maintaining an erection. By inhibiting PDE-5, avanafil helps to maintain higher levels of cGMP in the penis. This results in prolonged relaxation of the smooth muscles and increased blood flow, thereby facilitating erections when a man is sexually aroused. It's important to note that avanafil (Avana) and other PDE-5 inhibitors do not cause erections directly. Sexual stimulation is still required to initiate the release of nitric oxide and the subsequent cascade of events that lead to an erection.