How long does it take for Wellbutrin to work!! In people who lose weight as a side effect of Wellbutrin, it is possible to notice weight changes within eight weeks.
Signs that your antidepressant might not be working include: You feel more or the same amount of sadness, anxiety, or irritability after several weeks or months of taking the medication. You feel slightly better, but still feel that your depression is affecting your ability to function. You are having trouble sleeping.