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"Erectile dysfunction drug Viagra may worsen aortic aneurysm"

  • 비아그라 정품 (ingredient: sildenafil) may worsen abdominal aortic aneurysms, a study has found.

    An abdominal aortic aneurysm is a phenomenon in which a part of the abdominal aorta, the section where blood from the heart passes through the abdomen, loses elasticity and becomes thinner and inflates like a balloon.

    A team of researchers from the Aab Cardiovascular Research Institute at the University of Rochester, USA, has published results from a mouse study showing that Viagra can worsen abdominal aortic aneurysms (EurekAlert) reported on the 6th.

    Sildenafil, the main component of 비아그라 정품, inhibits the activity of phosphodiesterase 5 (PDE5), an enzyme that contracts the smooth muscle of blood vessels. said.

    First, the team surgically induced small abdominal aortic aneurysms in a group of mice.

    The research team divided the mice with an abdominal aortic aneurysm 7 days after surgery into two groups and administered sildenafil diluted in water (equivalent to 60 to 100 mg) to only one group every day for 4 weeks.

    After 4 weeks, the area of ​​the abdominal aortic aneurysm was enlarged by an average of 37% in the group of mice administered with sildenafil compared to the control mice not administered with sildenafil.

    In addition, the elastic fibers of the abdominal aortic aneurysm were weakened by 50%.

    This suggests that sildenafil aggravates the progression of the abdominal aortic aneurysm by disrupting the blood flow control function of vascular smooth muscle cells, the research team explained.

    Therefore, men with an aortic aneurysm or at high risk of an aortic aneurysm may be advised to avoid frequent use of 비아그라 정품, the researchers warn.

    The aorta consists of three layers, of which the middle layer is composed of smooth muscle cells that regulate blood flow by constricting and relaxing blood vessels. When vascular smooth muscle cells fail to function, the risk of an aortic aneurysm increases.

    The findings are published in the latest issue of the Journal of the American Heart Association.